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Natural Sleep Aid Supplements That Actually Work

If you aren't satisfied with your sleep quantity and quality, consider whether you're getting the right nutrients for a good night's sleep, or consider a REM sleep aid that works.
natural sleep supplements

Article At A Glance:

  • 70 million Americans struggle with sleep
  • Melatonin is most well-known natural sleep supplement
  • Lemon balm extract promotes relaxation
  • 5-HTP, GABA and L-theanine and glycine boost calming neurotransmitters
  • Vitamin B-6, magnesium, and calcium are minerals and vitamins that help promote sleep


If you're one of the 70 million Americans who struggle with sleep, you're probably aware that things like stress, caffeine, a heavy meal, or an uncomfortable bedroom can keep you up at night. If you've addressed those, but still aren't satisfied with your sleep quantity and quality, consider whether you're getting the right nutrients for a good night's sleep or consider a REM sleep aid.

In addition to keeping your body healthy and working well, numerous vitamins, minerals, amino acids for deep sleep and plant compounds also function as natural sleep aids. You can get many of them from a balanced diet, but possibly not enough, or not in the right combination to support good sleep. Other natural sleep aids come from plants that can be used medicinally. They have roots in Eastern medicine and scientific evidence behind them.

Adding natural sleep supplements may make a big difference in how quickly you fall asleep, how deeply you sleep, and the quality of your sleep.

Sleep supplements support improved sleep by boosting levels of certain neurotransmitters in your brain that promote relaxation, and by activating the brainwaves that move you through all of the necessary stages of sleep. Here's a short list of some that have been backed by research.

Melatonin sleep supplement

Melatonin – Before you can fall asleep, your body has to recognize that it's time to sleep – and that starts with melatonin. Melatonin is a hormone produced from the amino acid tryptophan. It's also probably the most well-known and widely used natural sleep supplement because it works well, and it's safe as long as you use it correctly. Learn our advice on how to use melatonin safely.

Melatonin is produced by a gland in your brain when it's dark, and it gets shut off when it's light. Therefore, it helps to synchronize your circadian rhythms, or your body's internal clock, by signaling when it's time to sleep and awaken. Melatonin production decreases with age. Many research studies, including some high quality randomized controlled studies (the gold-standard in research studies) have found that melatonin supplements are effective for people of all ages, in helping to regulate the body's clock and fall asleep faster. [1]

Sleep supplements that promote relaxation

Research on the following supplements suggests they may be helpful when your mind is wide awake and racing, but your body needs to sleep. They help to calm and relax you and quiet your mind so you can transition into sleep mode.

Lemon balm extract

This plant, known as Melissa officinalis L, is also used in integrative medicine to help manage anxiety, promote relaxation and reduce insomnia. It contains compounds that block the breakdown of GABA. In a small study on 20 people with mild to moderate anxiety and insomnia, taking lemon balm resulted in an 18% improvement in anxiety levels, and 42% reduction in insomnia. In fact, there were improvements in all measures of insomnia, including falling asleep, staying asleep and returning to sleep after waking in the middle of the night or early morning. [2]

Supplements that boost calming neurotransmitters

Neurotransmitters are chemical messengers that transmit signals throughout your brain and central nervous system, and thus, regulate everything from your nerves and muscles, to your memory and mood. And, yes, they also play an important role in sleep.


Serotonin is a neurotransmitter that's sometimes called "the feel-good hormone" because it promotes a feeling of calmness. Serotonin influences your appetite, digestion, mood, and sleep cycle. It also helps regulate your circadian rhythm, and it's required for the production of melatonin. [3]

Lower levels of serotonin are associated with more depression, anxiety, mood and sleep disorders. For many people, serotonin levels are lower in the winter months because they fall when there's less sunlight.

Unfortunately, serotonin isn't found in food, and you can't take a serotonin supplement because it can't cross into your brain. However, you can get more of the nutrients that help your brain make serotonin which will in turn make more melatonin. These include the B-vitamins, omega-3 fats, the amino acid tryptophan, and a compound called 5-HTP, which is made from tryptophan. Foods like fish, eggs, turkey, tofu, and nuts are good sources of these nutrients. You can also get more 5-HTP from a supplement. [4]

GABA and L-theanine

GABA (gamma-Aminobutyric acid) is known as the main inhibitory neurotransmitter, so it helps to block electrical impulses, and as such, it favors sleep. [5] Theanine is a non-protein amino acid found in both green and black tea. It promotes relaxation without drowsiness. Either of these can be used in supplement form as natural sleep aids, but research suggests that they work even better when taken together. [6]


Like GABA, the amino acid glycine also functions as an inhibitory neurotransmitter in the brain as well as the spinal cord. It triggers muscle paralysis during REM sleep by inhibiting neurons that move your muscles. [7] It also helps to lower your core temperature a bit so you can drift into deep sleep. [8] Several studies show it to be helpful in reducing the time to fall asleep and improving quality of sleep. In a study on women, most reported taking less time to fall asleep, having improved sleep quality, feeling more refreshed and clear-headed after sleep. [9,10] Therefore, glycine improves sleep quality.

Nutrients and vitamins that work behind the scenes

You might associate micronutrients like vitamins and minerals from foods and supplements with giving your body energy to get up and go, but they're equally as important for sleep. Micronutrients act as co-factors for different chemical reactions in your body. They're like the cogs in the wheels that run a machine (your body and brain) and without them, the machine doesn't work very well.

Vitamin B-6
, magnesium, and calcium

These are some of the most important micronutrients involved in sleep. They're essential for the synthesis and metabolism of serotonin, GABA and glycine. They're also involved in lowering your brain and body temperature which helps to initiate sleep, and also to help transition you the nonREM sleep stage. Research has linked low intake of these and other vitamins and minerals with poor sleep quality, including difficulty falling asleep, staying asleep, and non-restorative sleep. [11]

Sleeping is every bit as essential to your body as eating. It helps to boost your immune system and also to prevent chronic diseases down the road, so make sure you're doing all you can get the best sleep. Practice good sleep hygiene and work on ways to relax and destress so you can fall asleep easier, but also look for any gaps in your diet. In addition, consider taking a high-quality natural sleep supplement. REM Sleep combines all of the natural sleep aids mentioned in this article and the only sleep supplement made with MICROGEL™ technology to ensure maximum absorption of these nutrients that support all stages of sleep.


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About The Author

Dr. Giampapa is a world-renowned medical doctor, inventor, and surgeon specializing in anti-aging medicine. He recently received a nomination for the Nobel Prize for his groundbreaking stem cell research, as well as the Edison Award for the Healthycell nutritional supplement for cell health. He was also awarded the A4M Science & Technology award for his development of the BioMarker Matrix Profile – the first computer program to measure aging. Learn more about Dr. Vincent Giampapa.


1. Exogenous melatonin as a treatment for secondary sleep disorders: A systematic review and meta-analysis. 

2. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances.

3. Serotonin: its place today in sleep preparation, triggering or maintenance.

4. Diet promotes sleep duration and quality.

5. GABA mechanisms and sleep.

6. GABA and L-theanine mixture decreases sleep latency and improves NREM sleep.

7. REM sleep at its core – circuits, neurotransmitters, and pathophysiology.

8. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep.

9. Subjective effects of glycine ingestion before bedtime on sleep quality.

10. Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes.

11. Diet and Sleep Physiology: Public Health and Clinical Implications.

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