- What are telomeres?
- What is telomerase?
- Telomeres and disease
- Telomeres and aging
- Scientific Studies
- Reviews & Testimonials
Provides the nutrition that most directly impacts the health of your telomeres with botanical antioxidants, natural compounds that help maintain telomerase levels, nitric oxide enhancers, and methylating agents to inhibit homocysteine levels. Telomeres are protective caps at the end of the chromosomes in each of your cells that act as key components of your “cellular aging clock”. They help ensure the integrity of your genetic information during cell division. Longer telomeres allow a greater number of accurate divisions, or clean copies, in the life of your cells and are believed to help result in healthier aging. Telomeres have been linked to lifespan in several studies and short telomeres are found in a number of diseases.
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Healthycell is the result of over 20 years of expert research and ingredient sourcing into the factors that control and enhance the activity of cells.
Formulated by a team of nutrition and cell aging experts at Cell Health Institute who have practiced clinical cell health medicine for private patients over the past 20 years.
Methylating agents interact at the promoter region of DNA inside both stem cells and body cells (somatic cells). These compounds impact the process inside DNA that turns genes on and off, which controls the type of proteins the genes make. In fact, methylating agents can inhibit the cells from excreting harmful compounds that cause damage to cells and shorten telomeres.
Vitamin B6, Betaine
Telomere Maintenance Complex
|Amt Per Serving||%DV|
|VITAMINS (includes natural and organic sources)|
|Vitamin D |
Vitamin D is a group of fat-soluble compounds that enhance intestinal absorption of calcium, iron, magnesium, phosphate and zinc. The most important compound in this group is vitamin D3 (also known as cholecalciferol) and vitamin D2 (ergocalciferol). Cholecalciferol and ergocalciferol can be ingested from the diet and from supplements. The body can also synthesize vitamin D (specifically cholecalciferol) in the skin, when sun exposure is adequate. Other than regulating mineral levels, it may help prevent osteoperosis. Vitamin D defficiency can lead to a disease called rickets, as well as other health problems. The North American Dietary Reference Intake recommends 10 mcg (400 IU) per day.
(as pyridoxal 5-phosphate)
Vitamin B6 is a water-soluble vitamin that is part of the B complex group. It functions as a cofactor in many enzyme reactions in amino acid, glucose, and lipid metabolism. It helps make antibodies needed to fight disease, maintian normal nerve function, make hemoglobin, break down proteins, and keep blood sugar levels normal. High levels of vitamin B6 are found in foods such as tuna, turkey, beef, chicken, and sweet potato. Severe and chronic vitamin B6 defficiency can cause atrophic glossitis with ulceration, angular cheilitis, conjunctivitis, intertrigo, and neurologic symptoms of somnolence, confusion, and neuropathy, among other disorders. The North American Dietary Reference Intake recommends 2 mg per day.
|TELOMERE MAINTENANCE COMPLEX (TMC)|
This amino acid is necessary for the creation of proteins in the body. It can be obtained by adding red meat, poultry, fish and dairy to the diet. It converts into nitric oxide in the body and nitric oxide widens the veins to aid in blood flow, so it may support vascular health and improve exercise tolerance.
|Pueraria lobata root extract |
(70% total isoflavones)
Pueraria Lobata is a root plant native to Thailand and China that has traditional usage in alleviating migraines. The antioxidant activity of the isoflavonoids contained in Pueraria Lobata helps to suppress free radicals, thereby helping to keep the integrity of DNA from being damaged. In fact, the isoflavone inside this root has shown antimutagenic (anti-tumor) activity.
|Milk thistle seed extract |
The seeds of this plant have shown detoxifying and antioxidant properties. Sylimarin is the major active constituent of milk thistle, found in the seeds. Milk thistle’s beneficial effects on liver and gall bladder health have been known for centuries. There are seven major flavonoligans and one flavonoid in slylimarin that act as antioxidants and anti inflammatory agents, supporting the immune system.
|Bacopa monnieri extract |
(20% bacosides) (whole plant)
The Bacopa Monnieri extract is derived from a creeping vine plant that originated in the marshes of India, Asia and other continents. For centuries, natives in India used it as an Ayurvedic tonic “Brahmi”; a remedy for memory, calming and smooth muscle relaxing. It provides the phytoconstituents saponins, which include bacosides, and is a natural way to increase protein kinase activity and protein synthesis in the brain. It has an anti-aging effect on telomeres, the linear structures that form end caps on the tips of chromosomes, and that shorten with age. The telomeres provide protection to the chromosomes and DNA during cell division, to maintain and promote well being.
|Horny goat weed |
(epimedium) extract (10% icariin) aerial grass
Horny goat weed is an evergreen, flowering plant that has been used as Chinese medicine since ancient times. It contains flavonoids that protect the telomeres’ length, which is vital for maintaining its optimal performance in protecting the chromosomes and DNA from damage. The telomeres are linear cells and act like an end cap at the ends of the chromosomes. As cells divide telomeres get shorter and eventually become “senescent”, inactive or dead. Maintaining their optimal length provides anti-aging, antioxidant, and tumor inhibiting effects throughout the body.
|Korean ginseng root extract |
Ginseng root extract is a traditional Chinese medicinal herb used as a tonic since ancient times. It’s well known for the positive effects it has on fatigue and mental concentration. This Panax form of ginseng has pharmacological effects on multiple medical conditions; anti-stress, anti-oxidant, anti-cancer, diabetes, immune system, vascular system, nervous system.
|Ginkgo biloba leaf extract |
(24% ginkgo flavonglycosides, 6% sesquiterpene lactones)
Ginkgo biloba leaf extract (GBLE) is an herb originally from China. Studies showing scientific evidence supporting the benefit of GBLE for various body functions are ever increasing. As a powerful antioxidant, it has an anti-inflammatory effect on cells by suppressing the production of free radicals. There is scientific evidence supporting its use to improve blood and oxygen flow to the brain and extremities due to its relaxing effect on vascular walls and antagonistic action on platelet-activating factor. It also has neuroprotective properties and is considered to have a “cognitive activator” effect, which points to its use as a memory and mental awareness booster.
Betaine (Trimethylglycine) is structurally the amino acid called glycene, with three methyl groups attached, that is naturally occurring in beet roots. Around the 1900’s, betaine was discovered in sugar beet roots. Other food sources are broccoli, spinach, grains, legumes and shellfish. Betaine can lower homocystein by converting it to methionine. It metabolizes with folic acid, B12, choline, and increases S-adenosylmethionine (SAMe), a heart and liver protecting chemical. This methyl donor’s biochemical reactions can also help protect DNA from free radicals.
(Trans-resveratrol and polyphenol complex)
Fruitura™ is a proprietary botanical extract from red grape cells – a unique trans-resveratrol and polyphenol complex similar to the health-conducive red grape complexes found in red wine, but without the alcohol. These compounds support anti-inflammatory action, fight free radicals, may protect from ultra-violate rays and other environmental exposure (photo aging), and have potential protective and anti-aging effects on the brain. Most notably, these compounds may have effects on vascular health.
|Olive leaf extract |
(min. 6% hydroxytyrosol)
The olive tree (Olea europaea), has had a myriad of medicinal uses for centuries. Its popularity in the Mediterranean areas is vast because of its many health benefits, including immune system enhancement, heart health support and digestive support. Hydroxytyrosol, the active ingredient, supports anti-aging actions on telomeres – the linear cells that protect the ends of chromosomes. It contains many flavonoids, or plant pigments, that have antioxidant properties. Phenolic compounds are also present, which work similarly to protect healthy cells from free radicals. There are also antibacterial and anti-fungal properties to this extract.
Telomeres are an essential part of human cells that affect how our cells age.1 2 Telomeres are caps at the end of each strand of DNA that protect our chromosomes, like the plastic tips at the end of shoelaces.3 Without this coating, shoelaces become increasingly frayed until they can no longer function as shoelaces. Similarly, DNA strands that lose their telomeres, or have very short telomeres, become damaged and affect our health.
Telomeres protect the vital information in our DNA.4 DNA exists in every human cell as the genetic blueprint for a new cell to be born. Our DNA holds the code for all of our unique traits—like the color of our eyes—and it also acts as our body’s internal “control board” that determines how well we function, giving commands our body needs to do its job of staying healthy.
Since every organ in our body (skin, liver, heart, etc.) is made of cells, and these cells have DNA that must be safeguarded, it is clear that telomeres are vital to our health.
Our cells replenish by copying themselves. Each time a cell divides, the DNA unwraps and the information in the DNA is copied to the new cell being born. When the cell is finished dividing, the DNA comes back together. The cell’s telomeres lose a little bit of length each time this happens. When the telomeres become too short, essential parts of the DNA can be damaged during the replication process. Scientists have noticed that cells stop replicating when telomeres are shorter.5 Eventually, telomeres get too short to function properly as a safeguard for DNA, and it causes our cells to age and stop functioning properly.6 Therefore, telomeres can be thought of as the “cellular aging clock” in each cell. Healthy telomeres provide for a greater number of divisions, or clean copies, in the life of the cell; they therefore are a determinant of your cells’ lifespan.
Researchers use the length of a cell’s telomeres to determine the cell’s age and how many more times is will replicate. This information is important in aging research. There are natural extracts, that when purified and concentrated, show the ability to “turn on” the enzyme telomerase (hTERT) that acts to maintain telomere length.
1 A 2010 study from Harvard Medical School showed telomere shortening to be a root cause of cellular aging.
2 Sahin E, DePinho RA. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature. 2010;464:520-528.
3 Blackburn EH, Epel ES. Comment: Too toxic to ignore. Nature. 2012;490:169-171.
4 Eisenberg DTA. An evolutionary review of human telomere biology: the thrifty telomere hypothesis and notes on potential adaptive paternal effects. American Journal of Human Biology. 2011;23:149–167.
5 Genetic Science Learning Center, The University of Utah. “Are Telomeres the Key to Aging and Cancer?.” Learn Genetics 10 October 2011.
6 Aubert G, Lansdorp PM. Telomeres and aging. Physiological Reviews. 2008;88:557–579.
Telomerase is an enzyme that builds telomeres. Produced by the body, it can slow telomere shortening that occurs as we age. The amount of telomerase in our bodies declines as we get older1, so it becomes even more important as we age to provide our cells with the nutrients they require to keep telomerase levels adequate. Sufficient telomerase levels help to maintain telomere length and therefore improve cell aging, allowing cells to live longer and continue to function properly.
1 Eisenberg DTA. An evolutionary review of human telomere biology: the thrifty telomere hypothesis and notes on potential adaptive paternal effects. American Journal of Human Biology. 2011;23:149-167.
Studies have proven that maintenance of telomeres is essential to the health of a cell. Dysfunction in the body’s telomere maintenance process plays an integral role in cancer, certain rare diseases, and the human aging process. In fact, short telomeres have been connected to premature cellular aging1 2 and many age related diseases. For example:
In addition, when researchers analyzed people in perfect health who later died from heart disease, they found the death rate from heart attack was three times higher for men whose telomeres shortened the quickest. The death rate for women was more than two times higher.7
People with shorter telomeres in their immune cells had twice the risk of death from heart failure as patients with the longest telomeres. The study, published by the American Heart Association, found the highest-risk group had telomeres half the length of the lowest-risk group.8
1 Blackburn EH, Epel ES. Comment: Too toxic to ignore. Nature. 2012;490:169-171.
2 Armanios M, Blackburn EH. The telomere syndromes. Nature Reviews Genetics. 2012;13:693-704.
3 McGrath M, et al. “Telomere length, cigarette smoking, and bladder cancer risk in men and women.” Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):815-9.
4 Diehl MC, et al. “Elevated TRF2 in advanced breast cancers with short telomeres.” Breast Cancer Res Treat. 2010 Jul 13.
5 Aida J, et al. “Telomere lengths in the oral epithelia with and without carcinoma.” Eur J Cancer. 2010 Jan;46(2):430-8.
6 Delara et al. “Association of Longer Telomeres With Better Health in Centenarians.” The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 208. 63:809-812.
7 Delude, C. “Genetic clues to predicting life span: Inside chromosomes are telomeres that age as we age, and may serve as indicators of how long we’ll live.” Los Angeles Times. March 2, 2009. Retrieved July 6th, 2012.
8 Farzaneh-Fal et al. “Prognostic Value of Leukocyte Telomere Length in Patients With Stable Coronary Artery Disease: Data From the Heart and Soul Study.” Arteriosclerosis, Thrombosis & Vascular Biology. 2008. 28(7):1379-1384.
We inherit telomeres from our parents, and it is part of human nature for telomeres to shorten as we age, causing aging in our cells.1 2 3 For this reason, researchers have used telomere length as an indicator of genetic age, and therefore a predictor of longevity. Investigations show that proper diet, exercise, stress management, and social support may result in longer telomeres. This data supports lifestyle interventions as preventative medicine for age-related diseases.
Shorter telomeres impact our health in a negative manner4 because they prevent our cells from reproducing properly, which leads to our tissues degenerating and eventually dying.5
An interesting study in The Journals of Gerontology Series A: Biological Sciences and Medical Sciences showed that 100-year-olds in good health had “significantly longer” telomeres than those with health problems.
1 Jaskelioff M, et al. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 2011;469:102-107.
2 Eisenberg DTA. An evolutionary review of human telomere biology: the thrifty telomere hypothesis and notes on potential adaptive paternal effects. American Journal of Human Biology. 2011;23:149–167.
3 Aubert G, Lansdorp PM. Telomeres and aging. Physiological Reviews. 2008;88:557–579.
4 Armanios M, Blackburn EH. The telomere syndromes. Nature Reviews Genetics. 2012;13:693-704.
5 Jaskelioff M, et al. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 2011;469:102-107.
*ac-11 is the primary active ingredient in the Healthycell® Telomere Length formula.
MPBH organized the study and the study participants who were provided ac-11, and SpectraCell handled the telomere testing.
MPBH selected ten participants. Our target participant was over 50 years old, having a healthy lifestyle and no major disease issues and who we felt would be reliable. The participants, in turn, saw the project goal as exciting and we actually had too many volunteers. Participants received a monthly supply of ac11, 700 mg/day, at no cost. In return, they committed to paying for a yearly telomere test costing them about $250 per yearly test, for 3 years. They also filled out a brief survey form.
SpectraCell organized the whole blood cell draw by a nurse and a time-sensitive shipment of the samples to their lab back east. The lab calculated the mean telomere length of each participants leukocytes This average is graphed by age—and compared to the average of people in the same age range. The result is is presented visually. A person can clearly see how they compare in telomere length: below average compared to people in the same age range or above, and by how much. The data is also presented as a percentile score and percent change in that score since the last measure. That way each participant can easily track their progress over time. Part of our challenge is to not have drop-outs and we feel that presenting the first year’s results this way, is encouraging continued participation.
Our intent was to keep the process simple and the project economical. We are simply looking at change from each participant’s baseline average telomere length in response to on-going ingestion of AC-11, with the telomeres measured at months 12 and 16 or 24.
Eleven participants had their average telomere lengths assessed as baseline measures (10 plus an extra person in case someone dropped out.)
Then each month, participants were given the next month’s supply of 700 mg/day Optigenix ac-11. Twelve months later their telomere lengths were measured again and an assessment of their progress made
Out of 11 study participants, the leukocyte telomeres of nine participants lengthened. The leukocyte telomeres of two participants increased dramatically moving from telomere lengths typical of 70 and 60 year olds, to those typical of people in their forties. The average telomere length of one of the 11 stayed the same, and one declined–that latter participant was going through serious health issues.
If, by the third telomere test next March, those now below average telomere length move higher or to even above the mean, and those above the mean improve even further, that would be exceptionally good news, actually, amazing. It would represent hope to anyone who has had telomere-shortening health issues in the past, or an unfair roll of the dice via family genetics which can hand a child shorter telomeres to begin with.
According to some clinicians, stress, inflammation, and oxidative stress play key roles in telomere shortening.
A very general survey was administered to measure self-reported changes in these factors. At first glance it is difficult to generalize from the results. We had people with good nutrition and high stress do well, and those with good nutrition and high stress not do as well. Did the high stress people have better stress management? Our survey is too general to suss that out–same with oxidative stress.
The main point of the survey was actually pretty simple: if a participant’s telomeres shortened despite the ac-11, could stress, inflammation or poor nutrition have contributed to that negative result? Only 1 person’s telomeres shortened. He began confronting still unknown, negative health issues, about 6 months into the study.
The 2015 Nobel Prize in chemistry was awarded to scientists who did the studies on DNA repair. These scientists were clearly excited over DNA repair’s potential for helping people live longer lives with less disease.
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I have been searching for something for telomere length for a while. I keep hearing about astragalus and ta-65 but its too expensive. I bought this instead becasue it has ac-11 for DNA repair. I understand DNA repair can help contribute to longer telomeres. The other ingredients also have published papers on google scholar showing relation to telomere length. Great value.