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ac-11® 350mg Capsules

An organic Amazon rainforest extract of the Uncaria tomentosa plant that has been proven to enhance cell health by supporting your body’s natural ability to repair DNA, limit inflammation, clear out damaged cells, and enhance immune function – four powerful anti-aging functions critical to health as we age.
DNA contains the code that instructs your cells to make copies as needed throughout life. When your cells are damaged, this code becomes compromised. We experience up to one million DNA damage incidents every day, and the resulting accumulated damage underlies many conditions of aging and disease. The body contains enzymes to repair this damage, and with the proper nutrients these enzymes work optimally to help repair damaged DNA in body (somatic) cells and stem cells.
This sustainably wild harvested extract is supported by 17+ years of research, 40+ scientific peer-reviewed studies, and 10 U.S. patents.

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 2 reviews
by Branislav M. Healthycell®

In the beginning i had only dandruff, i don´t think i had a more severe diagnosis. This was almost 5 years ago. Since then i have been having a lot of stress and one day i found out that under the dandruff there is deep red skin. I was terrified of the findings and visited private dermatologist. She said that i have seborrheic dermatitis or psoriasis and that it doesn't matter which one it is specifically, that i will never get rid off it, that is like 2000 years old illness that cannot be cured completely and almost every time reappears again. She prescribed me corticosteroids and some kind of oil to put down the dandruff. The problem of her plan was,that when one day there was only a red skin and no dandruff,i applied the corticosteroids to try to cure the skin, however the next day dandruff was there again.Before i started using Ac-11 i had deep red flakes on my forehead where the hair grows, near ears and also in the back of the head. I used to have terrible itching of hair even when i was washing my hair every single day. I have been using Ac-11 for 7 months now and i can say that it is getting better. There are small parts of my skin that are completely white and healthy, there is no red skin anymore. Moreover, even the sick skin is just lightly red. I have a feeling that in the next 6 months i may be able to cure this completely, as it helps my immunity system to cure it. I was also using glasses while sitting in front of the computer,now i don´t need them anymore for this distance, i just use them outside to see clearly for distance. I will update this post in the next 6 months with my results.

by Sally B. Healthycell®

This product is NOT the same as the cat's claw that everyone else is offering! I found out about it 5 years ago during a visit to Dr. Vincent Giampapa's office in New Jersey. Dr. Giampapa has been nominated for a noble prize for his stem cell research. He is the leader in DNA repair research. 5 years ago he endorsed an amazing multi-vitamin (poor name for an amazing product). I figured "why not?" never expecting that it would put my painful, disfiguring nail psoriasis in total remission. 8 months later the supplement that included AC-11 was out of production. It appears now it is back. The Healthycell line of vitamins includes most of it but I believe that it was the AC-11 in the mix was a big key. It appears that this patented rainforest substance had been known to help many conditions and also people that just are trying to feel better and make the most of their lives. I am rating this five stars as I have no reason to believe I will not get a quick and amazing result for a very visible physical problem to which there is no cure and very little help. My dermatologist is tracking this with me. He is professor in dermatology at Yale Medical School in New Haven, CT.3/13/2016- It is about 3 weeks since I started taking Healthycell AC-11. I am posting a picture of my nail psoriasis now. Even to the untrained eye, you can see what an amazing difference this has made. My nails are not perfect but they are no longer separating from the top of the nail. I have had this autoimmune disease for about 18 years. Any one who know about psoriasis knows that there is no cure. It rarely responds to topical creams and biologicals are very expensive and come with many side effects. I am posting my results in my psoriasis group. I am hoping other people can get relief. I would think it would be helpful for general health and well being and could be an helpful with many other disorders. I will keep posting pictures over the next few months.

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What is ac-11 ® ?

ac-11 ® is an organic, water soluble rainforest plant extract from Uncaria tomentosa, a plant indigenous to the rainforest regions of Brazil and Peru. Pure, bioactive ac-11 ® is the only known plant extract in the world shown by research studies to enhance the cellular DNA repair process, among other cellular benefits, such as inflammation suppression and apoptosis inducement. ac-11 ® is the intersection of nature’s medicinal power and advanced phytonutrient science. ac-11 ® is classified as a phytonutrient. The term “phyto” originates from the Greek word for plant. Phytonutrients are the organic components of plants that promote health in humans and animals. The power of healing foods, vis-a-vis phytonutrients, lies within a food’s broad-based ability to prevent disease by nutritionally fortifying the biochemical processes that have been naturally selected by evolution to protect us from illness and other chronic conditions of aging.

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Discovered and Sourced in the Amazon

Mysterious and amazing, the Amazon Rainforest has been in existence for over 50 million years, naturally evolving with little disturbance from earth’s cataclysms, such as the ice ages. The complexities of life in the Rainforest, older and more intricate in many ways than life elsewhere, have only been appreciated by modern science over the past 30 years. The particular Amazon rainforests of Brazil and Peru are often called a “living pharmacy” for the depth, variety, and complexity of the botanical life forms that have developed there over many thousands of years. Researchers in biochemistry and pharmacology continue to make breakthrough discoveries studying the wondrous ecosystem of this region. In fact, scientists believe only 1 in 5 potentially life saving plants of the rainforest have been discovered to date. It is from the remote rainforest area that one such discovery has led to an innovative and exciting medicinal extract with an array of health-conducive properties not found anywhere else. This extract is one of the many critical keys to maintaining good health as we age.ac-11 ® was discovered in 1996 by Dr. Ronald W. Pero, PhD, a widely published scientist, university professor emeritus and expert in the fields of human biochemistry and DNA research. Dr. Pero’s work involving ac-11 ® was based on more than 30 years of research, including extensive field research on indigenous plant life in the Amazon region of South America. His observation of the CampaMed Indians for their unusually long and disease-free lifespan led him to study their behaviors. He witnessed the tribe Shamans, who were natural experts in plant-based rainforest medicines for over 2000 years, using a crude hot water extract of an indigenous plant called Uncaria tomentosa. The Shamans claimed the “tea” they made from this vine had powerful medicinal properties. Upon studying the tea back at his lab in University of Lund, Sweden, he isolated the active components, Carboxy Alkyl Esters (CAEs), and launched further studies with these active ingredients. To his amazement, these active ingredients had powerful effects at the cellular level on DNA repair, inflammation, and apoptosis – all critical elements of cell health related to many diseases seen in an aging population. Dr. Pero’s early work helped us understand the therapeutic value of ac-11 ® and gave rise to 40+ peer reviewed studies, articles and related data on this natural medicine from the rainforest.

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Sustainable Rainforest Harvesting

ac-11 ® is derived naturally from Uncaria tomentosa, a vine that grows wild in the Amazon rainforest. This vine is harvested in a sustainable and ethical manner under the authority of the Brazilian Institute of Environment and Renewable Natural Resources (IBAMA). This harvesting process ensures future maintenance of a natural balance in the rainforest. Authorization to harvest is granted through an ongoing sustainable management project directed by the government and based upon existing local herb availability whereby the amount of inner bark approved for harvesting is set. The harvest is taken (cut) at a point on the plant approximately three feet above ground level; the plant is then capped to ensure the integrity of the root structure and rapid regeneration of the vine. Additionally, new saplings of the vine are planted in a precise manner to ensure the continued viability of the harvesting area. The producer of ac-11 ® works in cooperation with the Floravida Institutes (Brazil) guidelines for biodiversity, conservation, and environmental education.

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Extraction Process, Ingredient Properties, and Manufacturer

ac-11 ® is created using a patented, wholly proprietary “aqueous hot water extraction” and purification process standardized to a minimum of 8% Carboxy Alkyl Esters (CAEs) concentration. Studies show that this active ingredient CAEs significantly enhance the body’s natural ability to repair damaged DNA.ac-11 ® differs from all other Uncaria tomentosa products, some of which are sold under the common name “cat’s claw,” in that its molecular composition is distinct by virtue of the patented extraction process. ac-11 ® is standardized, pure, water-soluble and micro-filtered to contain only low weight molecules (<10,000 Daltons). ac-11 ® is relatively alkaloid free(<0.05%) and is the only product available anywhere containing a patented class of CAE actives shown by extensive research to have healthy aging and natural DNA repair enhancement properties. No other Uncaria tomentosa product can make these claims. Moreover, ac-11 ® has been studied for efficacy and safety for over 17 years.ac-11 ® strictly conforms to the unique specifications set by the manufacturing methods and standardization claims. All of the standard industry accepted tests are performed to ensure the product meets requirements for sale in the United States and abroad. ac-11 ® is produced with the contracted services of Centroflora Group in Botucatu, Brazil, a U.S. Department of Agriculture approved and ISO 9002 certified facility operated in accordance with FDA (U.S. Food and Drug Administration) regulations and GMP (Good Manufacturing Practices) standards. Centroflora Group is one of the finest facilities in the world for the production of phytonutrient extracts.

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Safety and Efficacy

ac-11 ® is backed by an extensive efficacy and safety profile. Pure, bioactive ac-11 ® is the only known plant extract in the world shown by research studies to enhance the cellular DNA repair process. In fact, few other nutraceutical extract ingredients have been subjected to as much scientific study rigor as ac-11 ®.The purity of ac-11 ® comes from the clean, contaminant-free, chemical-free, toxin-free rainforest environment in which the plant is harvested and processed, as well as the patented molecular sieving (filtration) process it undergoes. By contrast, mild toxicity with long-term use is often observable in other Uncaria tomentosa products, especially the water-insoluble, alkaloid based extracts sold by other companies. The recommended daily dosage of ac-11 ® taken orally is 350 to 700 mg, depending on weight. For adults under 175 lbs, 350mg daily is recommended. For adults over 175 lbs, 700 mg daily is recommended.

ac-11® Health Benefits

ac-11® has proven cellular benefits. Years of ac-11® research and clinical use have proven its DNA repair, anti-inflammatory, apoptosis inducement, and immune effects at the cellular level.

The medical and scientific community over the past decade have linked the acceleration of DNA damage with chronic disease including cancer, adult onset diabetes, heart disease and other chronic maladies associated with poor health and aging. This community has also linked enhanced DNA repair capacity with self-healing and in some cases, reversal of these life threatening conditions. Although not a drug and subject to additional testing in humans, ac-11® has shown, in a variety of in-vitro, animal and human studies, the ability to help the body repair its own DNA.

ac-11® helps to normalize the expression of NF-kB in cells, thereby regulating cellular response to inflammation. NF-kB is a nuclear transcription factor that influences numerous gene-encoding proteins important in apoptosis (programmed cell death – a positive function), inflammation and cellular growth. A normal expression of NF-kB minimizes the hazards of excessive oxidative stress. An over-expression of NF-kB triggers increased inflammation. In one of the human studies, ac-11® demonstrated a positive effect on lymphocytes, increasing their lifespan and, by implication, enhancing the body’s immune system.

User Reported Health Benefits

The underlying improvement in cellular behavior that ac-11® causes manifests itself to the user as increased energy, enhanced immune function, and optimized overall health.

ac-11® Research

ac-11® Study 1

An active ingredient of cat’s claw water extracts: identification and efficacy of quinic acid
In 2005 after 8 years of research one of the primary CAEs was isolated and studied. These isolated of CAEs were found to be responsible for approximately half of the biological activity found in AC-11®. A chemotherapy drug (doxorubicin) was used to induce leucopenia (low white blood cells) in mice. Both AC-11® and QuinMax™ were shown to return white blood cells to normal at about the same rate within 2 weeks. Further study has been recommended to better understand the different results observed between the in vitro and in vivo models.Sheng, Y., Åkesson, C., Holmgren, K., Bryngelsson, C., Giamapa, V
Journal of Ethno pharmacology 2004 Download PDF

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ac-11® Extract Study 2

Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of uncaria tomentosa
This 1998 study was the first published study of AC-11® (formerly C-MED-100®). Due to Dr. Pero’s lifetime work in the area of DNA Repair as it related to oncology, a study was designed to look at the impact of AC-11® on human tumor cells. Apoptosis (programmed cell death) and the inhibition of proliferation of human tumor cells treated with AC-11® as observed in two (2) human leukemia cell lines. Equally important was that AC-11® induced a delayed apoptosis, 24 to 36 hours after exposure. This dose dependent induction of apoptosis remained from up to 72 hours. The significance of this is that the cancer cells studied would die “naturally” instead of replicating and growing unchecked. This unique activity of AC-11® is closely related to a properly functioning immune system and enhanced DNA Repair.

Sheng, Y., Pero, R.W., Amiri, A., Bryngelsson, C.
Anticancer Research 18: 3363-3368 (1998)

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ac-11® DNA Repair Study 3

Dna repair enhancement of aqueous extracts of uncaria tomentosa in a human volunteer study
This human volunteer study evaluating the effect of using 250 mg and 350 mg of AC-11® daily. Over an 8 week period DNA repair, after induction of DNA damage by a standard does of hydrogen peroxide (a known oxidant) was measured. There was a statistically significant decrease of DNA damage and a concomitant increase of DNA repair in the AC-11® supplement users (250 and 350my/day) when compared with the non-supplemented groups. Taken together this human trial was further confirmed the results of prior studies showing DNA repair enhancement by AC-11®, along with immune enhancement after AC-11® supplementation.

Sheng, Y., Li, L., Holmgren, K., Pero, R.W.
Phytomedicine, Vol. 8(4), pp. 275–28

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Study 4

Carboxyl alkyl esters (cae’s) of uncaria tomentosa augment recovery of sensorineural functions following noise injury.
Guthrie, O., Gearhart, C., Fulton, S., Fechter, L.
Brian Research. 1407; pp. 97-106 (2011) Download PDF

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Study 5

Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from ac-11
AC-11® has previously (1998) been shown to induce apoptosis and inhibit proliferation of tumor cells in vitro, and to enhance DNA repair, mitogenic response and white blood cells in vivo. This study, conducted in 2000 at the University of Lund in Sweden, studied the effect chemically induced leucopenia (low white blood cells) in a rat model. After treatment with doxorubicin, a chemotherapeutic agent known to induce leucopenia, AC-11® and Neupogen® ( a popular immune system drug) were administered. The results showed that both AC-11® and Neupogen®-treated groups recovered significantly sooner than the untreated doxorubicin group. However, the recovery by AC-11® treatment was a more natural process than Neupogen® because all fractions of white blood cells were proportionately increased while Neupogen® mainly elevated the neutrophil cells.

Sheng, Y., Pero, R.W., Wagner, H.
Phytomedicine, Vol. 7(2), pp. 137-143

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Study 6

Metabolic syndrome, hormones, and maintenance of t cells during aging
This study shows that maintenance of useful naïve and early memory T-cells is important to prevent the gradual loss of immune function often associated with aging. By studying the effects of high blood pressure, excess body fat around the waist and abnormal cholesterol levels (metabolic syndrome) as it relates to the microorganisms located in the gut and how they affect hormones and T cell metabolism leads us to new insights into the maintenance of the immune system/anti-aging.

Hsu, H., Mountz, J.D.
Curr Opin Immunol. 2010 August ; 22(4): 541–548

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Study 7

Historical development of uncaria preparations and their related bioactive components
AC11® history and scientific research is truly changing the way clinical nutrition is being viewed as it relates to the bioactive ingredients identified as CAEs. Examples include: anti-inflammation, nuclear fraction kappa beta (NF-kB) inhibition, and immune enhancement. The list has been documented and studied to include many more benefits. Concepts discussed in this study could revolutionize how we treat most illnesses since their origins would have in common basic metabolic mechanisms that regulate energy, plus hormone and protein synthetic events. The data presented provides strong evidence that AC11® contributes to human nutritional enhancement as a dietary supplement based upon its high content of QA and QAEs™.

Editor: Thomas, A.
DNA Damage Repair, Repair Mechanisms and Aging, 2010; 10: 223-236

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Study 8

AC-11®, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival in vivo
AC-11® significantly prolongs lymphocyte survival and functionality in vivo. The number of surviving and functional lymphocytes is clearly an immune system benefit in humans. It appears that the accumulative of lymphocytes in the AC-11®recipients is due to the anti-oxidative, anti-inflammatory, and DAN repair benefits associated with AC-11®. The test subjects used AC-11® daily for 63 days. The immune enhancement was clearly observable. Four weeks after stopping the use of AC-11® the immune benefits went away and the subjects returned to their prior base line.

Åkesson, C., Pero, R.W., Ivars, F.
Phytomedicine 10: 23–33 (2003)

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Study 9

Persistent response to pneumococcal vaccine in individuals supplemented with a novel water-soluble extract of uncaria tomentosa, ac-11
The human study looked at the immune effect of AC-11® on human volunteers in relationship to enhancing the vaccine benefits in individuals given the pneumococcal vaccine ( a pneumonia vaccine). The participants took AC-11® for 2 months prior to the vaccine being given. The results were statistically significant for immune enhancement and increased the effectiveness of the vaccine when the antibody titer response was measured at 5 months. This means that AC-11® was shown by this study to significantly enhance the persistence of protection from pneumococcal vaccination. No toxicity was observed.

Lamm, S., Sheng, Y., Pero, R. W.
Phytomedicine, Vol. 8(4), pp. 267–274

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Study 10

Antioxidant metabolism induced by quinic acid: increased urinary excretion of tryptophan and nicotinamide
This study examines one of the major bioactive esters found in AC-11®, quinic alkyl esters (QAE™). To stabilize and isolate a quinic acid product for research a quinic acid chelate, QuinMax™, was produced for laboratory research. The aim of this study was to isolate a primary active from AC-11®, quinic acid esters, and measure its effects on the endogenous production as pro-metabolite, of efficacious levels of nicotinamde and tryptophan. These important nutrients have important roles as antioxidants and also support DNA repair pathways. Additionally, nicotinamide and tryptophan support both the production of energy in the body, along sleep and mood enhancement. The result of this study clearly show that QuinMax™ increases internal antioxidant productions as shown by the elevation in serum thiols, along with enhancing DNA repair in humans via various pathways. This research confirms the positive health benefits observed with the ingestions of AC-11®.

Pero, R.W., Lund, H., Leanderson, T.
PHYTOTHERAPY RESEARCH, Phytother. Res.(2008)

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Study 11

The repair of cpds (uv-induced damage) in cell cultures over 24 hours using antibodies against cpd.
Exposure to sunlight creates DNA damage in skin cells. By linking adjacent bases to form cyclobutane pryimidine dimers (CPD). This is primarily done with thymine-thymine type dimmers (tt-dimers) but other DNA base pair combinations are possible. Our body naturally repairs about 50% of sun damage within 24 hours. The result of this study shows AC-11® significantly helps us to increase the repair to sun damaged cells/DNA. The repair increase at 24 hours was up to 70% to 75% compared with the untreated cells at 50%. These findings were quite consistent with the previous findings in the Estee Lauder study. It was, in part, based upon this research that initial Activar® and Aedre topical products were developed.

AGI Dermatics, Yarosh, D., nay, S. Confidential report #4. 2004.
Request from Optigenex

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Study 12

An extract of uncaria tomentosa inhibiting cell division and nf-kb activity without inducing cell death
AC-11® inhibits cancer division and cell proliferation, along with improved responses to inflammation. This study provides direct evidence that AC-11® inhibits NF-kB activity and it is due to this mode of action that AC-11®, in part, causes the inhibition of cancer cell division and proliferation. The ability of AC-11® to inhibit cancer cell division was also shown to not be caused by toxicity or apoptosis (programmed cell death), but by an unknown mechanism.

Åkesson, C., Lindgren, H., Pero, R.W., Leanderson, T., Ivars, F.
International Immunopharmacology 3 (2003) 1889–1900

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Study 13

Quinic acid is a biologically active component of the uncaria tomentosa extract ac-11®
One of the main carboxy akyl esters (CAE™) are quinic alkyl esters (QAEs™) this study clearly identifies quinic acid (QAEs™) as a potent biologically active component that is found in high concentrations in AC-11. Various endpoints were studied and compared with prior AC-11®studies, The QA equivalents (esters, slats, and chelates) found in AC-11® were shown to have much greater synergistic biological activity than QA alone. The natural synergy of all the CAEs found in AC-11® were found to be more active than any of its isolated components. Due to this discovery 3 additional patents have now been awarded.

Åkesson, C., Lindgren, H., Pero, R.W., Leanderson, T., Ivars, F.
International Immunopharmacology 5 (2005) 219–229

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Study 14

A water soluble extract from uncaria tomentosa (cat’s claw) is a potent enhancer of dna repair in primary organ cultures of human skin
DNA repair enhancement and anti-inflammatory properties are key molecular treatments that protect skin exposed to UV light from the sun. This study took skin cultures with and without AC-11® and microscopically analyzed for necrosis as well as level of pyrimidine dimers. The data clearly demonstrated reduced skin cell death from UV exposure, and this protection was attributed to a concomitant increase in DNA repair. Based on the results it is clear AC-11® was worthy of further consideration as a sunscreen product.

Mammone, T., Åkesson, C., Gan, D., Vojdani, A.
Phytotherapy Research

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Study 15

Quantitative analytical method development for the assessment of bioactive quinic acid-type esters and free quinic acid in dietary supplements
This study was inspired to study various methods on estimating CAEs/QAEs and free quinic acid thru searching beyond Cat’s Claw water extracts into other natural products including nutraceuticals. Prior research was conclude thru AC-11 and AIO samples. The study confirmed the previously published analytical data on CAEs and its related identified compounds found in AC-11. Secondly it showed improved CAEs procedures in showing the combined effects of AC-11 with other natural products such as AIO.

Pero, R.W., Lund, H.
International Journal of Biotechnology and Biochemistry, Vol. 7, No. 2: pp. 293-304.

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Study 16

Health consequences of catabolic synthesis of hippuric acid in humans
This study was done to review that the human gastrointestinal tract microflora are responsible for quinic acid metabolism. Not only to hippuric acid but more importantly to efficacious antioxidant amino acids and vitamins. Millions of people thru out China and India practiced urine therapy, i.e. drinking their own urine on a regular basis made famous by Ghandi. In basic terms the study is trying to figure out the health benefits of hippuric acid which is found in urine. In summary it is found that both tryptophan and nicotinamide (antioxidants) in conjunction with quinic acid (end product catabolite, hippuric acid) supplementation improves DNA repair. it also reduces the serum thiols which in turns enhances clinical responses to appetite, skin quality, join pain, fatigue: self-perceived health, and energy.

Pero, R.W.
Current Clinical Pharmacology,2010, 5,67-73

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Study 17

The role of dna damage repair in aging of adult stem cells
This study examines the theory that aging happens thru loss of DNA damage repair pathways poses a threat to the adult stem cells survival and longevity. Where normal cells have proper control of gene expressions and DNA replications while stem cells with the inability to repair may have altered patterns of proliferation and differentiation. This DNA damage leads to the emergence of cancer prone stem cells and human diseases. It also gives us a direct correlation of longitudinal analysis of DNA versus aging of the stem cells. In summary by intervening into the decline of DNA repair may improve stem cell function and delay aging and reduce the incidence of stem cell failure.

Kenyon, J., Gerson, S.L.
Nucleic Acids Research. 35:7557-7565, 2007. First published 26 Dec 2007;
Oxford Journals 10 September 2008

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Study 18

Enhanced dna repair, immune function and reduced toxicity of ac-11®, a novel aqueous extract from uncaria tomentosa

This early study looked at the effect various does of AC-11® would have on DNA repair and immune function. Toxicity was also examined. The study look over 8 consecutive weeks. Immune dysfunction is lined to oxidative stress and reduced DNA repair. Conversely, the decreases of DNA damage and improved DNA repair is associated with enhanced immune function. Both human volunteers and Wistar-Furth rats were studied. In both groups white blood cells were significantly increased after supplementation with AC-11®. Repair of single- and double-strand breaks, after whole body irradiation in rats were also significantly improved in the AC-11® treated group. There was no toxicity observed in wither study group.

Sheng, Y., Bryngelsson, C., Pero, R.W.
Journal of Ethnopharmacology 69 (2000) 115 – 126

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Study 19

Comparison of a broad spectrum anti-aging nutritional supplement with and without the addition of a dna repair enhancing cat’s claw extract
The intent of this human study was to examine the DNA repair effects of a broad spectrum multi-vitamin, with and without the addition of AC-11®. it is well known that a diet rich in vitamins and Phytonutrients is advantageous to health and provide support for healthy aging. Both formulas studied showed an improved ability to reduce oxidative stress and DNA damage. However the AC-11® based formula showed a clear enhancement of these effects plus a much stronger ability to enhance the natural DNA repair process. The two formulations were compared using four intermediate endpoint biomarkers: 8-OH guanine DNA adducts, serum thiols, and interleukins 1a and 1. Again, the AC-11® based formulation was much more effective at enhancing the natural cellular DNA repair process.

Pero, R.W., Giampapa, V., Vodjani, A
Journal of Anti-Aging Medicine; Volume 5, Number 4, 2002

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Study 20

Formulation and in vitro/in vivo evaluation of combining dna repair and immune enhancing nutritional supplements
This human study was undertaken to study various effects of AC-11® when combined with other synergistic ingredients which include zinc, niacinamide, and standardized mushroom extracts. After 30 days of taking this oral supplement the participant reported reduced pain, reduce fatigue, weight loss, along with a measured decreased in DNA damage and increase in DNA repair. One of the means used to measure increased DNA repair was the measurement of serum protein thiol.

R.W. Pero, A. Amiri, Y. Sheng, M. Welther, M. Rich
Phytomedicine 12 (2005) 255–263; Received 28 March 2003; accepted 8 January 2004

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Study 21

Dietary quinic acid supplied as the nutritional supplement aio + ac-11® leads to induction of micromolar levels of nicotinamide and tryptophan in the urine
This 21 day human trail study was designed using a natural supplement source of quinic acid call AIO + AC-11. It showed profound increases in tryptophan and nicotinamide urinary levels were paralleled to profound increases in quinic acid. It is proposed that DNA repair was enhanced strongly by quinic acid. So by combining natural quinic acid thru AIO and with AC-11 they show the lifestyle benefits and proof thru urine samples the results of the study.

Pero, R.W., Lund, H.
Phytotherapy Research, 25: 851–857 (2011)

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Study 22

In vivo treatment of humans with quinic acid enhances dna repair and reduces the influence of lifestyle factors on risk to disease
The oral administration of QuinMax™, a quinic acid chelate produced for research purposes, was designed to be studied as a natural DNA repair product after being isolated as a primary active ingredient in AC-11. This human study reported on a clinical design to evaluate if a group of exceptionally healthy individuals could be shown to have enhanced DNA repair based upon consumption of QuinMax™. The increase in DNA repair as measured by serum Thiols, had a concomitant increase in perceived wellness as measured by a self reported clinical index score, which was based upon a self-perceived status related to appetite, pain, fatigue energy and overall perceived health status. There was a clear linear relationship with the measured enhanced DNA repair and the wellness variables mentioned above. Very simply, people felt better as their DNA repair status improved.

Pero, R.W., Lund, H.
International Journal of Biotechnology and Biochemistry, Volume 5 Number 3 (2009) pp. 293–305

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AC-11® Patents

U.S. Patent No. 6,039,949, Filed: February 1997, Issued March 2000: entitled “Method of Preparation and Composition of Water Soluble Extract of the Plant Species Uncaria.”

This patent is directed to a method for preparing and manufacturing an Uncaria Sp. extract and for its administration generally for pharmaceutical purposes.

U.S. Patent No. 6,238,675 B1, Filed November 1999, Issued May 2001: entitled “Method of Preparation and Composition of a Water Soluble Extract of the Plant Species Uncaria for Enhancing Immune, Anti-Inflammatory and Anti-Tumor Processes of Warm Blooded Animals.”

This patent is directed to the composition of the Uncaria species extract described in the ‘949 manufacturing patent; namely carboxy alkyl esters (“CAE”) and its pharmaceutical use for enhancement of immune, anti-inflammatory and anti-tumor responses.

U.S. Patent No. 6,361,805 B2, Filed April 2001, Issued March 2002: entitled “Method of Preparation and Composition of a Water Soluble Extract of the Plant Species Uncaria for Enhancing Immune, Anti-Inflammatory, Anti-Tumor and DNA Repair Processes of Warm Blooded Animals.”

This patent covers the administration and pharmaceutical use of a purified Uncaria species., standardized to CAE content, for DNA repair.

U.S. Patent No. 6,964,784 B2, Filed March 2002, Issued November 2005: entitled “Method of Preparation and Composition of a Water Soluble Extract of the Bioactive Component of the Plant Species Uncaria for Enhancing Immune, Anti-Inflammatory, Anti-Tumor and DNA Repair Processes of Warm Blooded Animals.”

This patent covers the administration and pharmaceutical use of an isolated purified active ingredient of the Uncaria composition claimed in the ‘675 patent; namely, carboxy alkyl esters and, specifically, quinic acid alkyl ester.

U.S. Patent No. 7,579,023 B2, Filed November 2005, Issued August 2009: entitled “Method of Preparation and Composition of a Water Soluble Extract of the Bioactive Component of the Plant Species Uncaria for Enhancing Immune, Anti-Inflammatory, Anti-Tumor and DNA Repair Processes of Warm Blooded Animals.”

This patent is directed to a method for isolating a bioactive component of the Uncaria extract. The claims are further directed to include; the isolated bioactive component being a carboxy alkyl ester, a quinic acid analog, a quinic acid lactone and/or in a pharmaceutical composition providing broader coverage for the active ingredients and therapeutic claims.

U.S. Patent No. 7,595,064 B2, Filed October 2004, Issued September 2009: entitled “Method of Preparation and Composition of a Water Soluble Extract of the Bioactive Component of the Plant Species Uncaria for Enhancing Immune, Anti-Inflammatory, Anti-Tumor and DNA Repair Processes of Warm Blooded Animals.”

This patent is directed to a method of preparing and administering quinic acid or quinic acid salt to enhance DNA repair further identifying our active ingredients and application to DNA repair.

U.S. Patent No. 7,955,626 B2, Filed July 2009, Issued June 2011: entitled “Method for Enhancing the DNA Repair Process, Treating Disorders Associated with the DNA Repair Process, Enhancing Antitumor Response and Treating Disorders Associated with Anti-Tumor Response in Mammals by Administering Purified Quinic Acid and/or Carboxy Alkyl Ester.”

This patent is a continuation of the application that issued as U.S. Patent No.7,579,023. This patent covers the administration and pharmaceutical use of an isolated purified quinic acid alkyl ester or carboxy alkyl ester for DNA repair or treating disorders associated with a deficient DNA repair process.

U.S. Patent No. 7,947,312 B2, Filed May 2009, Issued May 2011: entitled “Method of Preparation and Composition of a Water Soluble Extract of the Bioactive Component of the Plant Species Uncaria for Enhancing Immune, Anti-Inflammatory, Anti-Tumor and DNA Repair Processes of Warm Blooded Animals.”

This patent is a continuation of the application that issued as U.S. Patent No.7,595,064. This patent is directed to a method of enhancing DNA repair or treating disorders associated therewith by administering quinic acid or quinic acid salt where the quinic acid or salt thereof may form an ammonium salt or chelate thereof and further broadening the coverage of our actives and therapeutic claims.

US Patent No. 8,372,449 Issued February 12, 2013: Method For Enhancing The DNA Repair Process, Treating Disorders Associated With DNA Repair Process, Enhancing Anti-Tumor Response And Treating Disorders Associated With Anti-Tumor Response In Mammals By Administering Purified Quinic Acid And/Or Carboxy Alkyl Ester

This patent is directed toward a method of enhancing the response to tumor formation and/or growth in a mammal by administering a pharmaceutical composition comprising a purified isolated compound selected from the group consisting of quinic acid and quinic acid salt,where said quinic acid and quinic acid salt may form an ammonium salt and/or chelate in an amount to inhibit TNF-alpha production to induce apoptosis of white blood cells having a bioassay efficacy using IC50 in HL-60 cells of approximately 500 micrograms per milliliter or less where application is other than topical.

US Patent No. 8,372,448 Issued February 12, 2013: Method For Enhancing The DNA Repair Process, Treating Disorders Associated With DNA Repair Process, Enhancing Anti-Tumor Response And Treating Disorders Associated With Anti-Tumor Response In Mammals By Administering Purified Quinic Acid And/Or Carboxy Alkyl Ester

This patent is directed toward a method for enhancing the response to tumor formation and/or growth in a mammal by inhibiting TNF-Alpha production or inducing apoptosis of white blood cells by administering a pharmaceutically effective amount of purified, isolated quinic acid alkyl ester having a UV absorption at approximately 200 nm and a bioassay efficacy using IC50 in HL-60 cells of less than 100 micro grams per milliliter, where said amount is effective to inhibit TNF-Alpha production or to induce apoptosis of white blood cells where administration is other than topical.

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 2 reviews
by Branislav M. Healthycell®

In the beginning i had only dandruff, i don´t think i had a more severe diagnosis. This was almost 5 years ago. Since then i have been having a lot of stress and one day i found out that under the dandruff there is deep red skin. I was terrified of the findings and visited private dermatologist. She said that i have seborrheic dermatitis or psoriasis and that it doesn't matter which one it is specifically, that i will never get rid off it, that is like 2000 years old illness that cannot be cured completely and almost every time reappears again. She prescribed me corticosteroids and some kind of oil to put down the dandruff. The problem of her plan was,that when one day there was only a red skin and no dandruff,i applied the corticosteroids to try to cure the skin, however the next day dandruff was there again.Before i started using Ac-11 i had deep red flakes on my forehead where the hair grows, near ears and also in the back of the head. I used to have terrible itching of hair even when i was washing my hair every single day. I have been using Ac-11 for 7 months now and i can say that it is getting better. There are small parts of my skin that are completely white and healthy, there is no red skin anymore. Moreover, even the sick skin is just lightly red. I have a feeling that in the next 6 months i may be able to cure this completely, as it helps my immunity system to cure it. I was also using glasses while sitting in front of the computer,now i don´t need them anymore for this distance, i just use them outside to see clearly for distance. I will update this post in the next 6 months with my results.

Hi Branislav,

We are pleased that you are finding relief from your condition while using ac-11. Although, we cannot claim to cure psoriasis or seborrheic dermatitis, we are very happy you believe ac-11 is responsible for the improvement of your condition. We are looking forward to your update, and thank you for your positive feedback.

Healthycell Customer Support
support@healthycell.com

by Sally B. Healthycell®

This product is NOT the same as the cat's claw that everyone else is offering! I found out about it 5 years ago during a visit to Dr. Vincent Giampapa's office in New Jersey. Dr. Giampapa has been nominated for a noble prize for his stem cell research. He is the leader in DNA repair research. 5 years ago he endorsed an amazing multi-vitamin (poor name for an amazing product). I figured "why not?" never expecting that it would put my painful, disfiguring nail psoriasis in total remission. 8 months later the supplement that included AC-11 was out of production. It appears now it is back. The Healthycell line of vitamins includes most of it but I believe that it was the AC-11 in the mix was a big key. It appears that this patented rainforest substance had been known to help many conditions and also people that just are trying to feel better and make the most of their lives. I am rating this five stars as I have no reason to believe I will not get a quick and amazing result for a very visible physical problem to which there is no cure and very little help. My dermatologist is tracking this with me. He is professor in dermatology at Yale Medical School in New Haven, CT.3/13/2016- It is about 3 weeks since I started taking Healthycell AC-11. I am posting a picture of my nail psoriasis now. Even to the untrained eye, you can see what an amazing difference this has made. My nails are not perfect but they are no longer separating from the top of the nail. I have had this autoimmune disease for about 18 years. Any one who know about psoriasis knows that there is no cure. It rarely responds to topical creams and biologicals are very expensive and come with many side effects. I am posting my results in my psoriasis group. I am hoping other people can get relief. I would think it would be helpful for general health and well being and could be an helpful with many other disorders. I will keep posting pictures over the next few months.

QUESTIONS FROM THE COMMUNITY

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Answers So Far..

  • Someone asked:
    I just ordered the anti aging package and the ac-11. I noticed to ProCell has ac-11 already in it. Is it OK to take 700mg of ac-11 daily? Thank You Steve
    • healthycell replied:
      Hi Steve, Yes, it is safe to take 700 mg of ac-11® as it is a natural extract from the inner bark of the Uncaria tomentosa vine. The Healthycell® products are designed to be taken together, so it is safe to take all of our products without the risk of mega-dosing. If you are taking the Healthycell® Cellular Aging Combo package not only is there ac-11® in Healthycell pro, but it is also present in DNA Repair and Telomere Length too. Therefore, when taking the Healthycell® Cellular Aging Combo package there is no need to additionally supplement the pure ac-11® capsules, although it is still safe to do so.